Whole-exome sequencing in 259 PCV patients revealed functional rare variants burden in collagen type I alpha 1 chain gene (COL1A1; \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$P=1.05\times {10}^{-6}$$\end{document}P=1.05×10−6) and potential enrichment of functional rare mutations at AMD-associated loci. This evidence concerns the gene COL1A1 and age-related macular degeneration.