TP53 and cancer: Intriguingly, while the anti-migratory and invasive activities of p53 induced upon treatment with the genotoxic agent SA have been clearly demonstrated in our previous study [19], p53 appears not to play an essential role in SA-mediated cell death, as loss of p53 enhances, but not mitigates, the cytotoxic effects of SA on cancer cells (Fig. 5M, N).