TP53 and neoplasm: We now suggest that Panx1 is directly transactivated by p53 (Fig. 5J) and exhibits its tumor-supporting effects, at least in part, by mediating ATP release and subsequent activation of the P2Rs/iCa2+/PI3K/Akt/NF-ĸB signaling axis to drive IL-6 expression under genotoxic stress.