NFKB1 and cancer: We found that in both untreated and SA-treated cancer cells, iCa2+ sequestration not only attenuated Akt phosphorylation at serine (S)473 but also diminished the phosphorylation of S276 on the p65 subunit of the transcription factor NF-κB (nuclear factor-kappa B) (Fig. 3J), whose main function is to transactivate various inflammatory cytokines, including IL-6 [40, 41].