The identified lead linkage variants (SLC17A1-rs1165196: pT269I, SLC17A3-rs942379: p.S370S, TATDN2-rs394558:p.V256I, and TMEM131L-rs6848033:p.R190R and the missense variant with the genotype homozygous for the alternate allele (SLC17A3 rs56027330_p.G279R) enrichening the affected members of Kuwaiti T1D families have not been previously linked with T1D and could be novel contributions to the existing literature. This evidence concerns the gene TMEM131L and type 1 diabetes mellitus.