The identified lead linkage variants (SLC17A1-rs1165196: pT269I, SLC17A3-rs942379: p.S370S, TATDN2-rs394558:p.V256I, and TMEM131L-rs6848033:p.R190R and the missense variant with the genotype homozygous for the alternate allele (SLC17A3 rs56027330_p.G279R) enrichening the affected members of Kuwaiti T1D families have not been previously linked with T1D and could be novel contributions to the existing literature. Here, SLC17A3 is linked to type 1 diabetes mellitus.