Given that 50% of patients with T1D are prone to developing diabetic kidney disease and that serum uric acid may be a modifiable risk factor of nephropathy in T1D49–51, the identification of a genetic variant that affects urate concentration is of high clinical significance, especially that high uric acid level has been implicated in β-cell dysfunction52 Our study can potentially contribute to the predictive roles of SCL17A1 rs1165196 and SLC17A3 rs942379 variants in the early diagnosis and prediction of T1D and its complications, particularly diabetic kidney disease. This evidence concerns the gene SLC17A3 and type 1 diabetes mellitus.