Notably, based on the analysis of ChIP-sequencing data for SREBF1 in ER+ breast cancer cell line (MCF-7), LUAD cell line (A549), and ESCA cell line (KYSE150 and TE-5), we found that the promoter of FASN was targeted by SREBF1 in these cells (Fig. 4g), further demonstrating that the FASN-mediated lipid metabolism was regulated by SREBF1. The gene discussed is FASN; the disease is breast cancer.