FLT3 and acute myeloid leukemia: Thus, while FLT3 mutations are less common in older adults in relative terms, due to the higher incidence of AML in older patients, the population-based absolute incidence of FLT3-mutated AML actually increases with age, with patients >60 years of age representing approximately 60% of all patients with FLT3-ITD mutated AML (Fig. 1) [26].