This dichotomy effect can also be seen in other CBX family members, such as CBX7, which is known to suppress cervical cancer, hepatocellular carcinoma and lung cancer,44–46 but the study also shows it could inhibit P16 and activate AKT-NF-κB-miR-21 pathway to promote cell survival and stem cell-like characteristics in gastric cancer.47 Here, CBX1 is linked to lung carcinoma.