To test whether mTOR/ROS inhibition will rescue the anti-tumor activity of lin28Tg CTLs, we generated P14 lin28Tg CTLs in the presence or absence of rapamycin/NAC treatment and P14 let-7Tg CTLs, and then injected them into B16gp33 tumor-bearing mice (Fig. 5i). This evidence concerns the gene MTOR and neoplasm.