To explore the clinical relevance of HuR function in the human PC/ISC niche, human ileal mucosal tissues were collected from four Crohn’s disease (CD) patients who required urgent/emergent intestinal resection because of severe complications (SC) such as intestinal perforation, peritonitis, and necrotizing enteritis as well as four healthy controls who had neither CD, nor emergency surgical disorders. This evidence concerns the gene ELAVL1 and peritonitis.