Although defective PCs and mitochondrial impairment are commonly observed in patients with IBD (Xiao et al, 2019; Ozsoy et al, 2022), the present study demonstrates for the first time that there were significant defects in PC/ISC niche in the intestinal mucosa of patients with critical surgical disorders after HuR inhibition. This evidence concerns the gene ELAVL1 and inflammatory bowel disease.