PHB1 and Crohn ileitis: HuR ablation in mice decreased the levels of PHB1 and HSP60 (Fig 4B and C); these two proteins are essential for mitochondrial integrity in the intestinal epithelium and loss of PHB1 or HSP60 results in defective PCs and leads to ileitis in mice (Jackson et al, 2020; Khaloian et al, 2020).