AhR-induced activation of EGFR may also occur in concert with traditional genomic signaling and may induce cancer cell proliferation [116,234], and has also been reported to cause resistance towards EGFR tyrosin kinase inhibitor (EGFR-TKI) treatment of adenocarcinoma through Src-mediated non-genomic signaling [115]. Here, EGFR is linked to adenocarcinoma.