EGFR and adenocarcinoma: In extension of the above, Wang et al [302] recently reported that long-term PM2.5 exposure [90 days) induced persistent activation of EGFR, cell proliferation, anchorage-independent growth, and tumor growth (xenograft mouse model) in human adenocarcinoma NCI-H1975 cells which harbors both the EGFR L858R and T790M mutations.