Suppression of AHR by hypermethylation has also been described for different cancer cell lines including the osteosarcoma cell lines U2OS and 143B, the diffuse large B-cell lymphoma cell lines U-2932 R2 and OCI-LY19, the chronic myeloid leukemia cell line K562 and the ALL cell lines Jurkat and REH [195], [196] (Fig. 4A). Here, AHR is linked to acute lymphoblastic leukemia.