PPARA and diabetic kidney disease: Similarly, we combined in silico deconvolution and network pharmacology approaches to identify PPARα-stimulated proximal tubular fatty acid oxidation as a key mechanism underpinning the renoprotective effects of intentional weight loss plus multi-modal pharmacotherapy in animals models of DKD [21, 22], highlighting the potential for fibrate therapy to synergise with intentional weight loss to mitigate DKD progression.