C1QA and neurodegenerative disease: C-type lectin domain family 7 member A (Clec7a) was described as highly up-regulated gene associated with different neurodegenerative diseases (28, –30), whereas, complement C1q subcomponent subunit A (C1qa) was described as a key signaling protein of disease-associated microglia leading to the neurotoxic activation of astrocytes (31).