Immunogenic cell death (ICD) is a regulated form of cell death characterized by the release of tumor-associated antigens (TAAs) and danger-associated molecular patterns (DAMPs) from dying cancer cells, including cell-surface exposure of calreticulin, extra cellular adenosine triphosphate (ATP), and high-mobility group box 1 (HMGB1) [7]. The gene discussed is HMGB1; the disease is neoplasm.