OTUD1 and disease arising from reactivation of latent virus: To further identify key genes in the mechanism of herpesvirus latent infection-induced stroke, we took the intersection of the hub genes identified by WGCNA and the differentially expressed genes in wild-type and mutant herpesvirus-infected brain tissues, resulting in three overlapping genes: OTUD1, NFIL3, and OSM (Figure 6A).