SIRT1 and type 1 diabetes mellitus: We also identified a link between these SIRT1 SNPs and islet autoantibody titers in T1D patients, whereby T1D patients with the GG genotype of rs10997866 and rs3818292 had higher IA-2A titers than those with the GA and AA genotypes, suggesting an association between SIRT1 risk alleles and IA-2A titers.