Elevated AhR expression also led to decreases in the Th17/Treg ratio and the activation of CD4+ T cells, CD8+ T cells, B cells, and NK cells.182 Th22 cells may be a potential therapeutic target in AIH, but more studies are needed to clarify the exact mechanism by which Th22 cells are involved in the pathogenesis and progression of AIH. Here, CD8A is linked to autoimmune hepatitis.