The genetic susceptibility of human leukocyte antigen-II (HLA-II) alleles in AIH and the liver infiltration of CD4+ T cells in AIH indicate the key role of CD4+ T cells in AIH.1 In this review, we focus on recent research and investigations on the differentiation of different CD4+ T-cell subsets in AIH and the expression of their related factors and discuss the therapeutic potential of targeting CD4+ T-cell subsets in AIH. This evidence concerns the gene CD4 and autoimmune hepatitis.