CD4 and systemic lupus erythematosus: Tregs inhibited the proliferation of CD8+ T cells and induced the production of IL-4 by CD8+ T cells at remission.43 Another study reported that in addition to a reduction in numbers, Treg cells from AIH patients had a diminished ability to produce TGF-β.44 In AIH-SLE/MTCD, the number and function of Foxp3+ Treg were abnormal, and CD4+CD25−IFN-γ+ and CD4+CD25−IL-17+ T cells were significantly increased.28 CD127 is usually presented on activated Teffs, while Tregs are usually CD127low/−.