IL10 and autoimmune disease: The pathogenicity of Th17 cells is closely related to autoimmune diseases, and this pathogenicity depends on IL-6, IL-1β, and IL-23.101 Single-cell RNA-sequencing showed that pathogenic Th17 cells showed increased proinflammatory genes such as IL17a, IL17f, and IL23r, and decreased immunomodulatory genes such as IL4, IL10, and Cd5l.