IL22RA1 and cardiovascular disorder: IL-22 receptor is composed of IL-22R1 and IL-10R2.47 IL-22R1 has a high affinity for IL-22 and is not expressed in lymphoid tissues, so IL-22 can only indirectly regulate immune cells through signaling.48,49 IL-22 binds to IL-22R and activates JAK and tyrosine kinase to subsequently exert its effects through JAK-STAT, extracellular signal-regulated kinase 1/2, and other signaling pathways.50,173,176 Th22 cells play both anti-inflammatory and proinflammatory roles in tumors, cardiovascular diseases, and immune diseases171 (Figure 3).