Both IL-10R2 and IL-22R1 are expressed in hepatocytes, and IL-22 binds to its receptor to induce the activation of JAK-STAT, MAPK, p38, and other pathways.49,177,178 The results of current studies on Th22 cells and IL-22 in AIH are contradictory. The gene discussed is IL22; the disease is autoimmune hepatitis.