Autoimmune diseases are characterized by an imbalance in immune tolerance to self-antigens, leading to abnormal immune active and autoimmune attacks on target organs.7 Similar to other autoimmune diseases, AIH is characterized by the activation of autoreactive T cells, overactivity of B cells, and increased autoantibody production.8 CD4+ T cells (or T helper cells, Th cells) are key players in adaptive immunity. This evidence concerns the gene CD4 and autoimmune disease.