Besides HIV-positive patients, T. marneffei infections have also been reported in other immunocompromised patients, such as transplant recipients, patients with systemic lupus erythematosus, those on corticosteroid therapy, with anti-interferon-gamma (anti-IFN-γ) autoantibody, and receiving anti-CD20 monoclonal antibodies or kinase inhibitors (4). The gene discussed is IFNG; the disease is systemic lupus erythematosus.