Moreover, polymorphisms in the A20/Tnfaip3 locus are associated with many inflammatory and autoimmune diseases, including IBD, SLE, and arthritis (Vereecke et al, 2009; Ma & Malynn, 2012; Catrysse et al, 2014; Martens & van Loo, 2020). This evidence concerns the gene TNFAIP3 and arthritic joint disease.