Given the importance of TNF in various human inflammatory diseases, including IBD and SpA, we generated a new TNF‐driven mouse inflammation model by targeting the AU‐Rich element (ARE) of the Tnf gene using a double guide‐RNA‐mediated CRISPR/CAS9 approach, resulting in a 107‐bp deletion in the 3′ UTR of the Tnf gene on Chromosome 17 (Fig EV1). The gene discussed is TNF; the disease is inflammatory bowel disease.