MALAT1 and Familial prostate cancer: Results from two other studies [32,33] indicated that rs6505162 polymorphisms in miRNA-423 might be a protective factor against prostate cancer (PCa) for the overexpression of miRNA-423-5p in PCa cells can induce inhibition of glucose and amino acids metabolism as well as down-regulate the expression and activity of MALAT1, which can promote PCa cells proliferation, migration, and invasion.