IL10 and colitis: In a IL-10-deficient mouse model, treatment of piroxicam-accelerated colitis IL-10-deficient (PAC IL-10−/−) mice with 400 mg/kg/day P. oleracea extract and proinflammatory parameters such as TNF-α, IL1β, and nuclear factor-kappa B (NF-κB) were reduced which confirm anti-inflammatory effects of the extract [72].