Ethyl acetate and ethanolic extracts of P. oleracea on inflammatory responses induced by LPS in RAW264.7 macrophages (in vitro model) and dextran sulphate sodium (DSS)-induced colitis in mice (in vivo model) indicated the inhibition of the serum proinflammatory cytokines (TNF-α, IL-6, and 1L-1β) in both models. The gene discussed is TNF; the disease is colitis.