RA inhibits the inflammatory response to the tumor microenvironment by inhibiting the expression of miR-155-5p in HCT8 and HCT116 cells, down-regulating the levels of transcription factor STAT3 and inflammatory factor Interleukin 6(IL-6), resulting in the inhibition of glucose consumption and lactic acid production in CRC cells, and the down-regulating expression of LDH and HIF-1α, and play the role of anti-Warburg effect (Xu et al., 2016). This evidence concerns the gene HIF1A and neoplasm.