LDHA and colorectal carcinoma: The glycolytic pathway is upregulated in ART1-expressing CT26 cells, while BCP can inhibit the expression of ART1-influenced glycolysis-related expression, such that of p-AKT, p-mTOR, c-Myc, PDK1 and LDHA, and it reduces lactate concentrations and ATP levels in CT26 cells, as shown using in vivo and in vitro models (Zhou et al., 2018) This suggests that BCP may inhibit ART1-induced glycolysis through the AKT/mTOR pathway, and it may play a role in inhibiting CRC cell proliferation and inducing apoptosis.