HK2 and colorectal carcinoma: In addition, Dioscin was shown to downregulate S-phase kinase-associated protein 2 (Skp2) protein levels and inhibit the expression of HK2 and aerobic glycolysis in CRC cells in vitro and in vivo by inhibiting Skp2 S72 phosphorylation and enhancing Skp2 ubiquitination and degradation in a cadherin 1(Cdh1) dependent manner (Zhou L. et al., 2020).