Pim1 is an oncogene promoting the growth and metastasis of CRC, which is highly expressed in CRC cells, and it has been found that pim1 can upregulate the expression of HK2 and LDHA in CRC cells, which may be related to the activation of the AMPK pathway under glucose deprivation (Zhang et al., 2018). Here, HK2 is linked to colorectal carcinoma.