PKM and colorectal neoplasm: AT-I downregulates the phosphorylation of proteins related to the AKT/mTOR pathway and the protein expression of GLUT1, LDH, HK2, and PKM2 in a dose-dependent manner in HCT116 and Colo205 cells, thus disrupting the glucose metabolism of colorectal tumors, followed by induction of apoptosis and reduced cell invasion (Wang K. et al., 2020).