AKT1 and colorectal carcinoma: Kallikrein-related peptidase, forkhead box class O6, and S100 calcium-binding protein A2 are highly expressed in CRC and play an activating role in glycolysis by activating PI3K/AKT/mTOR pathway and up-regulating GLUT1 expression (Li et al., 2019; Li C. et al., 2020; Wei et al., 2020).