PKM and colorectal carcinoma: In CRC, glycolysis-related enzymes and transporters (e.g., GLUT1, HK2, LDHA, PKM2) are highly expressed, and the upregulation of HIF-1, AMPK, c-Myc, PI3K/Akt/mTOR and other related pathways and transporters also promote the glycolysis process of CRC.