On xenograft tumor model of nude mice with SW1116 cells showed that 30 mg/kg DSG can reduce the weight of tumors in vivo, and inhibit the expression of Ki67 and proliferating cell nuclear antigen, Consistent with previous results in cells, DSG also inhibited the cAMP/PKA/CREB signaling pathway in tumor of nude mice (Li S. Y. et al., 2021). Here, DSG1 is linked to neoplasm.