PKM and colorectal carcinoma: Studies have found that Oxaliplatin-resistant CRC cells (OR-SW480 and OR-HT29) exhibit higher glycolysis rate and high mRNA and protein expression of PKM2, while scutellarin can inhibit the glucose metabolism rate and ATP production of cells by decreasing the PKM2 expression of OR-SW480 and OR-HT29 cells, leading to mitochondrial dysfunction and finally inducing cell apoptosis (Sun et al., 2021).