There are four types of HK isoenzymes, among which HK2 is abnormally highly expressed in the metabolic pathway of tumor cells, and its expression is closely associated with CRC proliferation and metastasis (Shinohara et al., 1994; Wilson, 2003; Katagiri et al., 2017; Huang et al., 2021). This evidence concerns the gene HK2 and neoplasm.