The results compiled for this review were classified according to different mechanism pathways targeted, including phytochemicals targeting PI3K/AKT/mTOR pathway (e.g., Thymoquinone and Daphnetin), AMPK pathway (e.g., Isoliquiritigenin and Resveratrol), HIF-1 (e.g., Worenine and Berberine), and c-myc (e.g., Astragalus saponins and Morin), and some phytochemicals directly affecting the glycolytic pathway of CRC without involving the above pathways. This evidence concerns the gene SETD2 and colorectal carcinoma.