HIF1A and colorectal carcinoma: In CRC cells resistant to 5-FU, glucose uptake and lactic acid production increase, and glycolysis-related enzymes and GLUT1 and MCT1/4 are significantly upregulated, which may be related to the activation of PI3K/AKT and the Wnt/β-catenin signaling pathway by upregulation of HIF-1α (Dong et al., 2022).