PKM and neoplasm: This previous study established an in vivo model using OR-SW480 cells injected into 4-week-old female immunodeficient nude BALB/c mice, showing that 10 mg/kg scutellarin reversed the drug resistance of oxaliplatin in the OR-SW480 mouse model, increased apoptosis induced by oxaliplatin, and significantly reduced protein expression of PKM2 and ATP production in the tumor (Sun et al., 2021).