A vivo experiment showed that halofuginone at 0.1 mg/kg for 14 days downregulated the tumor weight and AKT/mTORC1 expression in female BALB/c nude mice xenotransplanted with HCT116 cells, which was consistent with the results of an in vitro experiment (Chen et al., 2015). Here, AKT1 is linked to neoplasm.