KRAS and neoplasm: By analyzing the enrichment of different biological pathways among subtypes, it was clearly found that C2 was the subtype most significantly negatively correlated with tumor-promoting signal pathways (such as TGF-β signaling, PI3K-AKT mTOR signaling, KRAS signaling up, and epithelial–mesenchymal transition) and immune activation pathways (such as inflammatory response, complement, interferon alpha response, and interferon gamma response) among three macrophage-related subtypes (Supplementary Figure S2).