Several studies have revealed that intrahepatic vascular coagulation (IAOC) is a major cause of the onset and progression of liver fibrosis, cirrhosis, and liver cancer (Ganey et al., 2007; Sullivan et al., 2013; Miyakawa et al., 2015), and the inflammatory factor YKL-40 (Chi3l1) is associated with various inflammatory diseases. Here, CHI3L1 is linked to Cirrhosis.