Finally, CENPA, CDKN3, KPNA2, ARHGAP11A, KIF18A, ASF1B, HMMR, CDCA8, and CCNB2 were screened out by multivariate COX analysis and were considered to be the optimal model to compose the HCC prognostic scoring system with FPS = 0.875*CENPA+(-0.291*CDKN3)+0.414*KPNA2 +(-1.298*ARHGAP11A)+0.694*KIF18A+(-0.496*ASF1B)+ 0.292*HMMR+0.899*CDCA8+(-0.554*CCNB2) (Figure 5A). This evidence concerns the gene ASF1B and hepatocellular carcinoma.