Regular FOXO1 transcription inhibited epithelial mesenchymal transition (EMT) and transforming growth factor-β (TGF-β) expression, whereas dysregulation of EMT and TGF-β expression promoted HCC cell invasion and metastasis to other tissues when the FOXO1 transcription process was blocked (Dong et al., 2017). This evidence concerns the gene TGFB1 and hepatocellular carcinoma.