However, most of these regions identified in the SVM analysis were those implicated in the early phase of Braak pathological staging for tau and amyloid beta, such as the entorhinal cortex, fusiform, lingual, middle temporal, cingulate and temporal pole.42 Although we did not have biomarker evidence for tau and amyloid pathology in this study, it is reasonable to assume that our young healthy cohort was free from Ad pathology as well as other comorbidities found in patients with established Ad. Here, MAPT is linked to Alzheimer disease.