To the best of our knowledge, there is no existing data about the specific influence of MAPT on cerebral structure, but a previous study reported that patients with mild cognitive impairment (MCI) carrying MAPT haplotype H1 showed an increased volume in bilateral superior frontal gyri and precentral gyrus as well as in left inferior temporal gyrus and calcarine gyrus.11 However, the precise effects of MAPT on brain structure and how it interacts with APOE ε4 remain unclear. Here, APOE is linked to Cognitive impairment.