CRP and major depressive disorder: This review detected 11 studies which assessed CRP concentrations in people living with HIV, of which only four reported a significant association with depression or depressive symptoms.33,37,39,41 Notably, Rubin et al. 39 only saw this association in women living with HIV and Saloner et al. 41 only reported this association as an interaction between HIV, depressive symptoms, and neurocognition.