It has been suggested that the Klotho protein may protect against cognitive decline in aging and neurodegenerative disorders through multiple mechanisms: such as promoting optimal synaptic function via activation of N-methyl-d-aspartate (NMDA) receptor signaling, stimulating the antioxidant defense system, reducing inflammation, promoting autophagy and enhancing clearance of amyloid-β (34). Here, KL is linked to Mental deterioration.