APOE and familial hypercholesterolemia: Correlation of MMSE score and ApoE4 levels with metabolite data revealed the following findings (Figure 6): MMSE score displayed positive slight correlation coefficients with glutamic acid and ornithine; while the ApoE4 correlations had the positive correlations observed for: glutamine, cholinesterase inhibitor medication (ch-est inh), statin and hypercholesterolemia.