ALDH2 and Alzheimer disease: Our laboratory has previously shown that fibroblasts from AD patients with ALDH2*2 mutation or with ApoE ε4 allele overexpressing ALDH2*2 exhibit increased aldehydic load, oxidative stress, and mitochondrial dysfunction when compared to fibroblasts from healthy individuals, and that ethanol exposure further aggravated these dysfunctions (Joshi et al., 2019).