That study also performed a meta-analysis (1,824 cases, 4,300 controls) including six additional previous case-control studies in Asians (Kamino et al., 2000; Wang et al., 2008; Zhou et al., 2010; Komatsu et al., 2014; Ma and Lu, 2016; Wu Y. Y. et al., 2021) and found that the ALDH2*2 allele was a risk for AD, with an odds ratio of 1.38 (Ueno et al., 2022). Here, ALDH2 is linked to Alzheimer disease.