ALDH2 and atherosclerosis: ALDH2 is involved in oxidative and reductive reactions in vascular endothelial cells (Nannelli et al., 2020) and reduced ALDH2 activity is associated with the acquisition of an early aging phenotype of endothelial cells (Nannelli et al., 2018), atherosclerosis (Cai et al., 2023), and coronary artery disease (Xu et al., 2011; Yasue et al., 2019).