Our laboratory has previously shown that fibroblasts from AD patients with ALDH2*2 mutation or with ApoE ε4 allele overexpressing ALDH2*2 exhibit increased aldehydic load, oxidative stress, and mitochondrial dysfunction when compared to fibroblasts from healthy individuals, and that ethanol exposure further aggravated these dysfunctions (Joshi et al., 2019). Here, APOE is linked to Alzheimer disease.