Reduced ALDH2 activity increases 4-HNE-medicated reduction of anti-angiogenesis (Roy and Palaniyandi, 2020) and migration (Roy et al., 2020) in mouse coronary endothelial cells and is involved in 4-HNE-induced endothelial dysfunction and mitochondrial dysfunction in human umbilical vein endothelial cells (Nannelli et al., 2018; Figure 4B). This evidence concerns the gene ALDH2 and endothelial dysfunction.