Regardless, in addition to avoiding consumption of linoleic acid-rich cooking oils to reduce the aldehydic load in the brain, compounds that correct ALDH2 deficiency and activate ALDH2, such as Alda-1 (Chen et al., 2008), or supplementary acetic acid bacteria or yeast containing pure ALDH2 enzymes (Yamashima, 2020b), may provide a therapeutic strategy to slow down or reduce Alzheimer’s disease burden in the world’s aging population. The gene discussed is ALDH2; the disease is early-onset autosomal dominant Alzheimer disease.