(3) Although Aβ oligomers are known to damage neurons in vitro (Lambert et al., 1998; Kim et al., 2003; De Felice et al., 2007; Ono et al., 2009; Ahmed et al., 2021), neuronal cell death is virtually absent in APP or APP/PS1 transgenic mice modeling human Alzheimer’s disease. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.