Teriflunomide is a daily oral immunomodulatory therapy that selectively and reversibly inhibits dihydroorotate dehydrogenase, a key mitochondrial enzyme in the de novo pyrimidine synthesis pathway, leading to a reduction in the proliferation of activated T and B lymphocytes, and limiting their involvement in the inflammatory processes in MS [38]. Here, DHODH is linked to myeloid sarcoma.