INS and type 2 diabetes mellitus: The current study on the protective effect of β-sitosterol on the protein expression of insulin signalling molecules such as IR and GLUT4 in high fat diet induced type-2 diabetic rats elucidated the anti-diabetic potential of β-sitosterol and could be used as atherapeutic agent in the management of type-2 diabetes, which is a growing major health problem worldwide with a significant financial burden on society.