Tumor volume significantly reduced following anti‐PD‐L1‐DOX‐R848‐MIP‐3α/TKNP treatment (115.7 ± 54 mm3), which was 1.6‐fold (p < 0.01) and 3.9‐fold (p < 0.001) higher compared to the DOX‐R848‐MIP‐3α and DOX‐R848‐MIP‐3α/TKNP cocktail, respectively. This evidence concerns the gene CD274 and neoplasm.