The reduced expression of tumor antigens and the upregulation of anti‐apoptotic molecules by the tumor cells, together with the formation of the immunosuppressive tumor microenvironment (TME) consisting of numerous immunosuppressive factors, such as transforming growth factor‐beta (TGF‐β), IL‐10, regulatory T cells, and immune checkpoint components, are considered as major reasons for the exhaustion of effector lymphocytes, resulting in the immune evasion of the tumors.1, 2, 3. Here, TGFB1 is linked to neoplasm.