Subsequently, the CAPs trigger the immunogenic cell death (ICD) in tumor cells via Bax/Bak‐1 and caspase apoptotic pathways, which is along with the exposure or release of tumor antigens, danger‐associated molecular pattern (DAMP) molecules such as calreticulin, ATP and high mobility group protein B1 (HMGB1) molecules, and type I interferons (IFNs).13, 14, 15. Here, HMGB1 is linked to neoplasm.