Then pseudotime plots (Figure S6e) revealed dynamic trajectories of naive NKT evolving and developing into critical clusters (cluster‐0, ‐1, ‐2, ‐3) as CD84/TRGC2/TRAC reset core feedback rhythm to evolve TKTL1+/JCHAIN+/PCM+/TRGC2+ NKT repertoire so as able to address evolving immune‐evasion from refractory tumor cells or variants. This evidence concerns the gene TKTL1 and neoplasm.