In this study, the relative expression of Sfrusocs2, Sfrusocs4, Sfrusocs5, and Sfruken was maintained at a low level in the early stages of infection progress, suggesting that these genes might be involved in the immune response in S. frugiperda infected by B. bassiana, which indicates that S. frugiperda could activate JAK/STAT-mediated immune responses by downregulating the repressors Sfrusocs2, Sfrusocs4, Sfrusocs5, and Sfruken (Kausar et al., 2022). This evidence concerns the gene SOAT1 and infection.