Furthermore, we propose the SPRR and MUC gene families, as well as several other previously identified genes also found in our analysis, are a promising set of genes potentially associated with disease etiology (CCL26, CPA3, POSTN, CTSC, ANO1, CRISP3, SPINK7). With more mechanistic insight, these genes may become useful for clinical evaluation of EoE as part of a genetic panel. This evidence concerns the gene CRISP3 and eosinophilic esophagitis.