This study assessed the mRNA expression levels of various tight junctions, including occludin (OCLN), claudin-3 and −7 (CLDN3 and CLDN7), desmoglein 3 (DSG3), and thymic stromal lymphopoietin (TSLP) in 30 individuals with Allergic Rhinitis (AR) and 30 non-allergic controls. This evidence concerns the gene DSG3 and allergic rhinitis.