CYP3A4 and cancer: Besides, patients with cancer often are polymedicated; thus, it is essential to check the possible drug-drug interactions between OAAs and cytochrome P450 3A4 inhibitors (amiodarone, digoxin, antihistamines, atorvastatin, carbamazepine, corticosteroids, etc.)since they can increase the plasma concentrations of many of the antiangiogenic protein kinase inhibitors.