Besides, patients with cancer often are polymedicated; thus, it is essential to check the possible drug-drug interactions between OAAs and cytochrome P450 3A4 inhibitors (amiodarone, digoxin, antihistamines, atorvastatin, carbamazepine, corticosteroids, etc.)since they can increase the plasma concentrations of many of the antiangiogenic protein kinase inhibitors. Here, WEE1 is linked to cancer.