2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone found in Reynoutria japonica Houtt., is proven to be effective against the progression of colon carcinoma by inducing necroptosis in cancer cells through JNK activation and mitochondrial ROS production (35). The gene discussed is MAPK8; the disease is colon carcinoma.