Thus, homozygous Tg(Nes-cre)1Wme/J mice (MGI: 2161775) and tamoxifen-treated Tg(Nes-cre/ERT2)4Kag (MGI:3817325) mice both have microencephaly and hydrocephalus [PMID: 16971543]25. The gene discussed is NES; the disease is microcephaly.