TNF and chronic recurrent multifocal osteomyelitis: There are several treatment options available for the management of patients with CRMO and that include, but are not limited to, non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, bisphosphonates, anti-TNF agents, or disease-modifying anti-rheumatic drugs (DMARDs), such as methotrexate or sulfasalazine.