NFKB1 and prostate carcinoma: NF-kB activation leads to immune activity, inflammation and cell proliferation whilst also upregulating the transcription genes that produce collagenases, cell adhesion molecules and inflammatory cytokines. It is also associated with the transcription of genes involved in cell survival and inhibiting apoptosis. Inflammation can result in persistent oxidative stress in cancer cells and ROS may give these cancer cells a survival advantage. EA has been shown to prevent prostate cancer growth, by inhibiting inflammatory pathways including the NF-kB pathway [32].