IGHE and eosinophilic esophagitis: However, the inadequate manifestation of an immediate reaction to food products, the less predictive value of SPTs (skin prick tests), and the insufficient improvement with immunoglobulin E (IgE) therapy invalidate the speculation that EoE is solely an IgE-mediated food reaction, similar to the pathogenesis of atopic disorders such as asthma and eczema [12].