MMP9 and cataract: UV rays can also harm your eyes, including cataracts and eyelid pores, skin cancer, and a variety of environmental pores and skin conditions.102, 103, 104 Under changes in pores and skin cells induced by UVB radiation, down-regulation of nc886 results in depleted phosphorylation of PKR by MAPKs and increased expression of proinflammatory cytokines, matrix metalloproteinase-9 (MMP-9), type IV collagenase, and cyclooxygenase (COX-2), which in the end boost up inflammatory responses and pores and skin aging.105