,10 STAT3, C/EBP, TAZ, NF-κB, Wnt, PI3K/AKT/mTOR, MAPK, and JNK in GBM cells are demonstrated to be directly associated with PMT.11, 12, 13, 14, 15, 16 Additionally, changes in the microenvironment (artificial treatment, metabolism, mRNA splicing) activate these pathways.6 This evidence concerns the gene AKT1 and glioblastoma.