,10 STAT3, C/EBP, TAZ, NF-κB, Wnt, PI3K/AKT/mTOR, MAPK, and JNK in GBM cells are demonstrated to be directly associated with PMT.11, 12, 13, 14, 15, 16 Additionally, changes in the microenvironment (artificial treatment, metabolism, mRNA splicing) activate these pathways.6 Here, MAPK8 is linked to glioblastoma.