YAP1 and gastric cancer: ,102 Several studies have found that KDM4A not only modulates the growth and invasion of GC by activating the KDM4A/YAP1 pathway101,103 but also sensitizes GC cells to cisplatin, 5-FU, and docetaxel by interacting with pro-apoptotic coiled-coil domain containing 8 (CCDC8).104