,49, 50, 51, 52 In acute myeloid leukemia (AML), KDM4A is overexpressed and promotes the KDM4A-PAF1 signaling-mediated transcriptional program by removing methyl groups from H3K9me3 and H3K9me27, regulating 9 genes associated with poor prognosis of AML and thus maintaining AML self-renewal and survival, while KDM4A knockout can induce apoptosis of AML cells.51 The gene discussed is PAF1; the disease is acute myeloid leukemia.