EGFR and lung carcinoma: The ADAM12 gene is overexpressed in many subtypes of lung cancer and promotes tumorigenesis via proteolytic shedding of EGFR ligands.71, 72, 73, 74, 75 The Jagged-1 (JAG1) gene has been identified as a diagnostic biomarker for lung cancer and promotes tumorigenesis by mediating the Notch intracellular pathway.76