ESR1 and breast cancer: For example, KDM4A and KDM4D are co-overexpressed in basal breast cancer, while the KDM4A level is higher in infiltrating breast duct carcinoma (IBDC) than in breast fibroadenoma,79 and KDM4B is overexpressed in both estrogen receptor (ER)-positive breast cancer and triple-negative breast cancer.80