Four-and-a-half LIM domain 1 (FHL1) is a key component of the mechano-transducer machinery in the heart, and KDM4A can occupy the FHL1 promoter in response to transverse aortic constriction and up-regulate FHL1 levels by removing methyl groups from H3K9me3 during cardiac hypertrophy.21 The gene discussed is FHL1; the disease is cardiac hypertrophy.