E2F1 and cancer: Wang et al found that KDM4A can associate with E2F1, enhance the transcriptional activity of the E2F1 target genes pyruvate dehydrogenase kinases (PDKs) PDK1 and PDK3 by binding to their promoters, and thus promote cancer cell proliferation and survival by modulating the switch between glycolytic metabolism and mitochondrial oxidation.97