MORC2 and Charcot-Marie-Tooth disease: For instance, MORC2 mutations are associated with some disorders,34, 35, 36 including Charcot-Marie-Tooth (CMT) disease,37, 38, 39, 40, 41 spinal muscular atrophy,24,42,43 and neurological disorders,44 especially Charcot-Marie-Tooth disease type 2Z (CMT2Z),38,45 thus allowing a better understanding of the genetic architecture of MORC2.