Reliable evidence has shown that c-Myc plays a vital role in the glucose metabolism of cancer cells, which can promote tumor growth and metastasis.52, 53, 54 Guddeti et al demonstrated that MORC2 is a glucose-inducible gene and serves as a target gene of c-Myc to promote lactate dehydrogenase A (LDHA) transcription and BC cell migration at high glucose concentrations.46 This evidence concerns the gene LDHA and breast cancer.