,86 Wang et al demonstrated that MORC2 interacted with DNA methyltransferase 3A (DNMT3A) to form a complex upstream of the Hippo regulator neurofibromatosis 2 (NF2) and kidney and brain protein (KIBRA) promoters, leading to their DNA hypermethylation and transcriptional repression, Hippo signaling pathway activation, and cell growth inhibition, with implications for cancer cell stemness and tumorigenesis.78 Here, MORC2 is linked to cancer.