Meanwhile, MORC2 can interact with SIRT1 and represses the NDRG1 promoter activity, resulting in reduced acetylation levels of histones H3 and H4 in the NDRG1 promoter, thereby repressing NDRG1 gene transcription and further promoting CRC cell migration and pulmonary metastases.80 Here, SIRT1 is linked to colorectal carcinoma.