IRF3 and rheumatoid arthritis: There was also an increase in pro-inflammatory miR-146a, similar to monocytes in children with sJIA and some patients with rheumatoid arthritis (RA) or psoriatic arthritis (PsA).42, 43, 44 MiR-146a is believed to exert a crucial role in the “fine-tuning” of the monocyte NF-κB signaling pathway, capable of reducing NF-κB and IRF3 activity.45