Although Ecn exhibits multiple pharmacological effects, its anti-tumor effect has only recently been preliminarily verified in esophageal, lung, and colorectal cancer.23, 24, 25 In this current study, we demonstrated that Ecn significantly inhibited the growth and metastasis of human BC cells possibly through p38 and Wnt/β-catenin signaling pathways in vitro and in vivo. The gene discussed is MAPK14; the disease is breast cancer.